›› 2011, Vol. 23 ›› Issue (1): 42-045.doi: 10.3969/j.issn.1004-616x.2011.01.011

• 论著 • Previous Articles     Next Articles

Protein level and clinical significance of clusterin in peripheral blood derived from epithelial ovarian cancer patients

LU Ne-nan1，XIAO Ting2，ZHANG Ying2，YAO Hong-wen1，HAN Nai-jun2，CHENG Shu-jun2，WU Ling-ying1，GAO Yan-ning2，   

  1. 1. Department of Gynecologic Oncology, Cancer Hospital and Institute, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100021; 2. Beijing Key Laboratory for Carcinogenesis andCancer Prevention, Cancer Hospital and Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing
  • Received:2010-08-22 Revised:2010-11-15 Online:2011-01-30 Published:2011-01-30
  • Contact: GAO Yan-ning

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Abstract: To evaluate clusterin protein level in the peripheral blood samples from epithelial ovarian cancer patients, and to explore its clinical significance. METHODS: Peripheral blood samples were obtained from 137 patients with epithelial ovarian cancer, 12 with borderline ovarian tumor, 10 with benign ovarian tumor, 41 with benign pelvic lesion and 58 healthy women. The plasma clusterin level was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean level of plasma clusterin in epithelial ovarian cancer patients was significantly higher than that in healthy women (P=0.021). The mean plasma clusterin in epithelial ovarian carcinoma patients with metastasis was significantly higher than those without (P＜0.01). The level of plasma clusterin did not correlate with the stage, grade and lymph node metastasis. CONCLUSION: Plasma clusterin level was increased in the peripheral blood of ovarian cancer patients. In epithelial ovarian carcinoma，the level of plasma clusterin did correlate with distant metastasis.

Key words: clusterin, ovarian cancer, ELISA